General Information

  • ID:  hor004658
  • Uniprot ID:  Q8S8N3(27-81)
  • Protein name:  CLAVATA3/ESR (CLE)-related protein 6
  • Gene name:  CLE6
  • Organism:  Arabidopsis thaliana (Mouse-ear cress)
  • Family:  CLV3/ESR signal peptide family
  • Source:  Plant
  • Expression:  [CLE6p]: Mostly expressed in roots, seedlings, stems and flowers, and, to a lower extent, in apex and siliques.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Arabidopsis (genus), Camelineae (tribe), Brassicaceae (family), Brassicales (order), malvids, rosids, Pentapetalae, Gunneridae, eudicotyledons, Mesangiospermae, Magnoliopsida (class), Spermatophyta, Euphyllophyta, Tracheophyta, Embryophyta, Streptophytina (subphylum), Streptophyta (phylum), Viridiplantae (kingdom), Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0030154 cell differentiation; GO:0045168 cell-cell signaling involved in cell fate commitment; GO:2000023 regulation of lateral root development; GO:2000067 regulation of root morphogenesis
  • GO CC:  GO:0005576 extracellular region; GO:0048046 apoplast

Sequence Information

  • Sequence:  RILRTYRPTTMGDMDSQVLLRELGIDLSKFKGQDERRFLVDSERVSPGGPDPQHH
  • Length:  55(27-81)
  • Propeptide:  MANLILKQSLIILLIIYSTPILSSQARILRTYRPTTMGDMDSQVLLRELGIDLSKFKGQDERRFLVDSERVSPGGPDPQHH
  • Signal peptide:  MANLILKQSLIILLIIYSTPILSSQA
  • Modification:  T47 Hydroxyproline;T50 Hydroxyproline
  • Glycosylation:  T50 O-linked (Ara...) hydroxyproline
  • Mutagenesis:  NA

Activity

  • Function:  Extracellular signal peptide that regulates cell fate.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q8S8N3-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor004658_AF2.pdbhor004658_ESM.pdb

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Physical Information

Mass: 731553 Formula: C274H443N85O85S2
Absent amino acids: ACNW Common amino acids: RDL
pI: 7.71 Basic residues: 11
Polar residues: 13 Hydrophobic residues: 13
Hydrophobicity: -88.91 Boman Index: -16884
Half-Life: 1 hour Half-Life Yeast: 2 min
Half-Life E.Coli: 2 min Aliphatic Index 72.55
Instability Index: 5111.45 Extinction Coefficient cystines: 1490
Absorbance 280nm: 27.59

Literature

  • PubMed ID:  NA
  • Title:  NA